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Recently, there have been two letters published which imply data quality issues with The Health Improvement Network (THIN) database. Apart from the potential conflict of interest of the authors, we feel that their claims are not substantiated and we demonstrate this below (Validation comments.pdf).

Since public debate often degenerates into a long series of exchanges, we have decided to make researchers aware of our interpretation of the stated concerns via our website.

  Comments on letter to PDS
  Publications on validation
i Van Staa TP, Parkinson J. Re: Use of cyclo-oxygenase 2 inhibitors (COX-2) and prescription non-steroidal anti-inflammatory drugs. Pharmacoepidemiol Drug Saf, 2007; 16:1253-4 (NSAIDS) in UK and USA populations: implications for COX-2 cardiovascular profile
ii Van Staa TP, Parkinson J. Response to: validation studies of the health improvement network (THIN) database for pharmacoepidemiology research by Lewis et al. Pharmacoepidemiol Drug Saf, 2008; 17:103-4
 
 
 
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